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6-O-Nicotinoylscutebarbatine G

Names

[ CAS No. ]:
1206805-30-2

[ Name ]:
6-O-Nicotinoylscutebarbatine G

[Synonym ]:
1,3,4-Cyclopentatriene-1-carboxylic acid, (3R,4a'R,5'S,6'R,6a'R,10'R,10a'S,10b'R)-1',2',4,4'a,5,5',6',6'a,9',10',10'a,10'b-dodecahydro-5'-hydroxy-4'a,6'a,7',10'b-tetramethyl-5-oxospiro[furan-3(2H),3'-[3H]naphtho[2,1-b]pyran]-6',10'-diyl ester
(3R,4aR,5S,6R,6aR,10R,10aS,10bR)-5-Hydroxy-4a,6a,7,10b-tetramethyl-5'-oxo-1,2,4',4a,5,5',6,6a,9,10,10a,10b-dodecahydrospiro[benzo[f]chromene-3,3'-furan]-6,10-diyl bis(1,3,4-cyclopentatriene-1-carboxylate)

Biological Activity

[Description]:

6-O-Nicotinoylscutebarbatine G is an alkaloid that can be isolated from Scutellaria barbata.6-O-Nicotinoylscutebarbatine has cytotoxic activities against HONE-1, KB and HT29 cells with IC50s of 3.1, 2.1 and 5.7 μM, respectively[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[References]

[1]. Dai SJ, et al. Two new neo-clerodane diterpenoid alkaloids from Scutellaria barbata with cytotoxic activities. J Asian Nat Prod Res. 2009;11(5):451-6.  

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
732.3±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C32H36N2O8

[ Molecular Weight ]:
576.64

[ Flash Point ]:
237.9±26.4 °C

[ Exact Mass ]:
546.225342

[ PSA ]:
134.14000

[ LogP ]:
3.55

[ Vapour Pressure ]:
0.0±5.4 mmHg at 25°C

[ Index of Refraction ]:
1.611

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds