1-Methyl-2-[(6Z,9Z)-6,9-pentadecadiene]-4(1H)-quinolone

Names

[ CAS No. ]:
120693-52-9

[ Name ]:
1-Methyl-2-[(6Z,9Z)-6,9-pentadecadiene]-4(1H)-quinolone

[Synonym ]:
4(1H)-Quinolinone,1-methyl-2-(6Z,9Z)-6,9-pentadecadienyl
1-methyl-2-(6Z,9Z)-6,9-pentadecadienyl-4(1H)-quinolinone
1-methyl-2-[(6Z,9Z)-pentadeca-6,9-dienyl]-4(1H)-quinolone
1-methyl-2-<(6Z,9Z)-6,9-pentadecadienyl>-4(1H)-quinolone

Biological Activity

[Description]:

Methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone9 is an antagonist of angiotensin II receptor (IC50=48.2 μM). Methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone9 is a quinolone alkaloid from Evodia rutaecarpa[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Research Areas >> Endocrinology

Signaling Pathways >> GPCR/G Protein >> Angiotensin Receptor

[Target]

IC50: 48.2 μM (Angiotensin II Receptor)[1]

[In Vitro]

Methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone9 is an antagonist of angiotensin II receptor (IC50=48.2 μM)[1].

[References]

[1]. Hyun SL, et al. Inhibition of Angiotensin II Receptor Binding by Quinolone Alkaloids from Evodia rutaecarpa. Phyotherapy Resarch, VOL. 12, 212–214 (1998)

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₅H₃₅NO

[ Molecular Weight ]:
365.55200

[ Exact Mass ]:
365.27200

[ PSA ]:
22.00000

[ LogP ]:
6.72420