1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone
Names
[ CAS No. ]:
120693-53-0
[ Name ]:
1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone
Biological Activity
[Description]:
1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone, a quinolone alkaloid, is a diacylglycerol acyltransferase inhibitor and angiotensin II receptor blocker, with IC50s of 20.1 μM and 34.1 μM, respectively. 1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone shows potent anti-Helicobacter pylori activity with the MIC of 10 μg/mL[1][2][3].
[Related Catalog]:
[Target]
IC50: 20.1 μM (diacylglycerol acyltransferase)[3], 34.1 μM (angiotensin II receptor)[2]
[In Vitro]
1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone shows anti-Helicobacter pylori activity, with the MIC of 10 μg/mL, and has no effect on Helicobacter pylori urease activity at the concentration of 300 μg/mL[1]. 1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone (5-500 μM) shows a dose-dependent diacylglycerol acyltransferase (DGAT) inhibition, with an IC50 of 20.1 μM[3]. 1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone (5-20 μM) inhibits leukotriene biosynthesis in human polymorphonuclear granulocytes, with an IC50 of 10.1 μM[4].
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C23H31NO
[ Molecular Weight ]:
337.50