Draflazine

Names

[ CAS No. ]:
120770-34-5

[ Name ]:
Draflazine

[Synonym ]:
Draflazine
Draflazinum
Draflazina

Biological Activity

[Description]:

Draflazine (R-75231) is a ENT1 inhibitor. Draflazine (R-75231) completely reverses the hypersensitivity in the complete Freund’s adjuvant (CFA) model of mechanical hyperalgesia and the carrageenan inflammation model of thermal and mechanical hyperalgesia[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[Target]

ENT1[1]

[References]

[1]. Maes SS, et al. Antihyperalgesic activity of nucleoside transport inhibitors in models of inflammatory pain in guinea pigs. J Pain Res. 2012;5:391-400.

Chemical & Physical Properties

[ Density]:
1.338g/cm3

[ Boiling Point ]:
755.9ºC at 760mmHg

[ Molecular Formula ]:
C₃₀H₃₃Cl₂F₂N₅O₂

[ Molecular Weight ]:
604.51800

[ Flash Point ]:
411ºC

[ Exact Mass ]:
603.19800

[ PSA ]:
104.69000

[ LogP ]:
6.49650

[ Vapour Pressure ]:
9.69E-23mmHg at 25°C

[ Index of Refraction ]:
1.618