FPL64176

Names

[ CAS No. ]:
120934-96-5

[ Name ]:
FPL64176

[Synonym ]:
2,5-Dimethyl-4-[2-(phenylmethyl)benzoyl]-1H-pyrrole-3-carboxlic acid methyl ester
MFCD00274043
methyl 4-(2-benzylbenzoyl)-2,5-dimethyl-1H-pyrrole-3-carboxylate

Biological Activity

[Description]:

FPL64176, a nondihydropyridine compound, is a potent agonist of L-type Ca2+ channels with an EC50 value of 16 nM[1][2].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel

Research Areas >> Cardiovascular Disease

[References]

[1]. Zheng W, Rampe D, Triggle DJ. Pharmacological, radioligand binding, and electrophysiological characteristics of FPL 64176, a novel nondihydropyridine Ca2+ channel activator, in cardiac and vascular preparations. Mol Pharmacol. 1991 Nov;40(5):734-41.

[2]. Baxter AJ, Dixon J, Ince F, Manners CN, Teague SJ. Discovery and synthesis of methyl 2,5-dimethyl-4-[2- (phenylmethyl)benzoyl]-1H-pyrrole-3-carboxylate (FPL 64176) and analogues: the first examples of a new class of calcium channel activator. J Med Chem.

Chemical & Physical Properties

[ Density]:
1.174g/cm3

[ Boiling Point ]:
547.8ºC at 760mmHg

[ Melting Point ]:
144 - 145 °C

[ Molecular Formula ]:
C₂₂H₂₁NO₃

[ Molecular Weight ]:
347.40700

[ Flash Point ]:
285.1ºC

[ Exact Mass ]:
347.15200

[ PSA ]:
59.16000

[ LogP ]:
4.23990

[ Vapour Pressure ]:
4.72E-12mmHg at 25°C

[ Index of Refraction ]:
1.6

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

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