H-Leu-Pro-Pro-OH

Names

[ CAS No. ]:
121305-26-8

[ Name ]:
H-Leu-Pro-Pro-OH

[Synonym ]:
1-(1-L-Leucyl-L-prolyl)-L-proline
L-Proline,1-(1-L-leucyl-L-prolyl)

Biological Activity

[Description]:

LPP Tripeptide is a blood pressure lowering tripeptides. LPP Tripeptide can be used for research of hypertension[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Others >> Others

[References]

[1]. van der Pijl PC, et al. Pharmacokinetics of proline-rich tripeptides in the pig. Peptides. 2008 Dec;29(12):2196-202.

Chemical & Physical Properties

[ Density]:
1.247g/cm3

[ Boiling Point ]:
572.6ºC at 760mmHg

[ Molecular Formula ]:
C₁₆H₂₇N₃O₄

[ Molecular Weight ]:
325.40300

[ Flash Point ]:
300.1ºC

[ Exact Mass ]:
325.20000

[ PSA ]:
103.94000

[ LogP ]:
1.00250

[ Vapour Pressure ]:
1.33E-14mmHg at 25°C

[ Index of Refraction ]:
1.556

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TW3675000

CHEMICAL NAME :: L-Proline, 1-(1-L-leucyl-L-prolyl)-

CAS REGISTRY NUMBER :: 121305-26-8

LAST UPDATED :: 199506

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C16-H27-N3-O4

MOLECULAR WEIGHT :: 325.46

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JKXXAF Japanese Kokai Tokyo Koho Patents. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #90-240027