Triphendiol

Names

[ Name ]:
Triphendiol

[Synonym ]:
2H-1-Benzopyran-7-ol, 3,4-dihydro-3-(4-hydroxyphenyl)-4-(4-methoxyphenyl)-
3-(4-Hydroxyphenyl)-4-(4-methoxyphenyl)-7-chromanol
NV-196
UNII-6I62LZU21D
Triphendiol

Biological Activity

[Description]:

Triphen diol is a phenol diol derivative, which has excellent anticancer activity against pancreatic cancer and cholangiocarcinoma, and can induce pancreatic cell apoptosis through two mechanisms, caspase-mediated and caspase-independent[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

[In Vitro]

Triphen diol (0-10 μM, 48-120 h)可抑制胰腺细胞增殖并诱导细胞凋亡，作用于 HPAC 和 PANC-1 细胞的 IC50值为 8 μM，作用于 MIAPaCa-2 细胞的 IC50 值为 0.8 μM[1]。 Apoptosis Analysis[1] Cell Line: Human pancreatic cell lines HPAC, MIAPaCa-2, and PANC-1 Concentration: 10 μM Incubation Time: 48 h Result: Induced caspase-dependent apoptosis in MIAPaCa-2 and PANC-1 cells, 60% of the cells were in the early stage of apoptosis, and 30% of the cells were in the late stage of apoptosis. Reduced Bcl-2 levels in MIAPaCa-2 and HPAC cell lines.

[In Vivo]

Triphen diol(50 mg/kg, oral gavage, daily, 15 days) 在雄性移植了 MIAPaCa2 细胞系的 Balb/c 裸鼠中，可以显著抑制肿瘤的增殖，并且可以与吉西他滨联用显示更好的疗效[1]。

[References]

[1]. Xiaohong Wang, et al. Triphendiol (NV-196), development of a novel therapy for pancreatic cancer. Anticancer Drugs. 2011 Sep;22(8):719-31.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
517.2±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₂H₂₀O₄

[ Molecular Weight ]:
348.392

[ Flash Point ]:
266.6±30.1 °C

[ Exact Mass ]:
348.136169

[ PSA ]:
58.92000

[ LogP ]:
4.40

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.638