AN-3485

AN-3485 is a benzoxaborole analog, Toll-Like Receptor(TLR) inhibitor with IC50 values ranging from 18 to 580 nM.

Signaling Pathways >> Immunology/Inflammation >> Toll-like Receptor (TLR)

Research Areas >> Inflammation/Immunology

IC50：AN-3485 inhibits TLR2-, TLR3-, TLR4-, and TLR5-mediates TNF-a, IL-1b, and IL-6 release with IC50 values of human PBMCs (103±68 nM, 68±63 nM, 72±33 nM)and isolated monocytes (77±26 nM; 18±6.7 nM; 32±6.5 nM) [1] .

[1]. Dong C, et al. Inhibition of Toll-like receptor-mediated inflammation in vitro and in vivo by a novelbenzoxaborole. J Pharmacol Exp Ther. 2013 Feb;344(2):436-46.

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