TCV-309 chloride
Names
Biological Activity
[Description]:
TCV-309 chloride is a platelet activating factor (PAF) antagonist. (1) TCV-309 chloride specifically inhibited PAF-induced aggregation of rabbit and human platelets. (2) TCV-309 chloride selectively inhibited the PAF-induced hypotension, hemoconcentration and death with ED50 values of 2.7, 6.4 and 1.7 micrograms/kg (i.v.), respectively. TCV-309 (chloride) most potently protected mice from death induced by PAF and due to anaphylactic shock with ED50 values of 2.1 and 2.6 micrograms/kg (i.v.), respectively. (3) TCV-309 chloride also reversed PAF-induced hypotension and endotoxin-induced hypotension in rats with ED50 values of 3.3 and 1.2 micrograms/kg (i.v.), respectively.
[Related Catalog]:
[References]
[Related Small Molecules]
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Cyclosporin A
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H2DCFDA
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0MPTP hydrochloride
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GW4869
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Etomoxir
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TD139
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Mitoquinone mesylate
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GSK2795039
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JC-1
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BAPTA-AM
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AP 20187
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Setanaxib (GKT137831)
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D-Luciferin
|
Crotaline
Chemical & Physical Properties
[ Molecular Formula ]:
C30H34BrClN4O4
[ Molecular Weight ]:
629.97
[ Storage condition ]:
2-8℃