CFM 1571 hydrochloride

CFM 1571 hydrochloride is the stimulator of the nitric oxide receptor, soluble guanylate cyclase (sGC) with an EC50 and IC50 of 5.49 μM and 2.84 μM, respectively. Soluble guanylate cyclase (sGC) is a key signal-transduction enzyme activated by nitric oxide (NO). CFM 1571 (hydrochloride) (compound 32) has the potential for the research of cardiovascular and other diseases[1][2].

Research Areas >> Cardiovascular Disease

Signaling Pathways >> GPCR/G Protein >> Guanylate Cyclase

sGC[1][2]

Assessment of Pharmacokinetics (PK) profile of CFM 1571 (hydrochloride) (compound 32) in rat[1] . compd Cmax (ng/mL) AUC (ng/h/mL) tmax (h) F (%) 32b 6.4 61.1 2.7 12 b: dosed at 5 mg/kg po.

[1]. Selwood DL, et al. Synthesis and biological evaluation of novel pyrazoles and indazoles as activators of the nitric oxide receptor, soluble guanylate cyclase. J Med Chem. 2001;44(1):78-93.

[2]. Evgenov OV, et al. NO-independent stimulators and activators of soluble guanylate cyclase: discovery and therapeutic potential. Nat Rev Drug Discov. 2006;5(9):755-768.