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Thalidomide-5-COOH

Names

[ CAS No. ]:
1216805-11-6

[ Name ]:
Thalidomide-5-COOH

[Synonym ]:
1H-Isoindole-5-carboxylic acid, 2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-
2-(2,6-Dioxo-3-piperidinyl)-1,3-dioxo-5-isoindolinecarboxylic acid
MFCD32063447

Biological Activity

[Description]:

Thalidomide-5-COOH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-COOH can be connected to the ligand for protein by a linker to form PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> Ligand for E3 Ligase

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

[References]

[1]. Liu K, et, al. Design and biological characterization of hybrid compounds of curcumin and thalidomide for multiple myeloma. Org Biomol Chem. 2013 Aug 7;11(29):4757-63.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
648.3±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C14H10N2O6

[ Molecular Weight ]:
302.24

[ Flash Point ]:
345.9±30.1 °C

[ Exact Mass ]:
302.053894

[ LogP ]:
0.22

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.676

[ Storage condition ]:
2-8℃

Related Compounds