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paritaprevir

Names

[ CAS No. ]:
1216941-48-8

[ Name ]:
paritaprevir

[Synonym ]:
(2R,6S,12Z,13aS,14aR,16aS)-N-(Cyclopropylsulfonyl)-6-(5-methylpyrazin-2-carboxamido)-5,16-dioxo-2-(phenanthridin-6-yloxy)-1,2,3,6,7,8,9,10,11,13a,14,15,16,16atetradecahydrocyclopropa(E)pyrrolo(1,2-a)(1,4)diazacyclopentadecine-14a(5H)-carboxamide
Veruprevir anhydrous
ABT450

Biological Activity

[Description]:

Paritaprevir (ABT-450) is a potent non-structural protein 3/4A (NS3/4A) protease inhibitor with EC50s of 1 and 0.21 nM against HCV 1a and 1b, respectively.

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HCV
Research Areas >> Inflammation/Immunology

[Target]

EC50: 1 nM(HCV 1a), 0.21 nM(HCV 1b)[1]


[In Vitro]

Paritaprevir demonstrates in vitro antiviral activity against HCV GT1-4 and GT6 (EC50 range, 0.09 to 19 nM), with an EC50 of 0.09 nM against GT4a[2].

[In Vivo]

The combination of paritaprevir, ritonavir, ombitasvir (an NS5A protein inhibitor), and dasabuvir (an NS5B non-nucleoside polymerase inhibitor) with or without RBV has been approved to treat HCV genotype 1 infections1[1].

[References]

[1]. Smith MA,et al. Profile of?paritaprevir/ritonavir/ombitasvir plus dasabuvir in the treatment of chronic hepatitis C virus genotype 1 infection. Drug Des Devel Ther.?2015 Nov 13;9:6083-94.?

[2]. Schnell G, et al. Hepatitis C Virus Genotype 4 Resistance and Subtype Demographic Characterization of Patients Treated with Ombitasvir plus Paritaprevir/ritonavir. Antimicrob Agents Chemother. 2015 Aug 17. pii: AAC.01229-15.


[Related Small Molecules]

Asunaprevir | Sofosbuvir | Simeprevir | Ledipasvir | Artemisinin | Elbasvir | NIM811 | MK-5172 | velpatasvir | Ombitasvir | Danoprevir (ITMN-191) | Glecaprevir | Celgosivir (hydrochloride) | Alisporivir | R-1479

Chemical & Physical Properties

[ Molecular Formula ]:
C40H43N7O7S

[ Molecular Weight ]:
765.87700

[ Exact Mass ]:
765.29400

[ PSA ]:
208.50000

[ LogP ]:
6.34660

[ Storage condition ]:
-20℃

Related Compounds