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TSHR antagonist S37

Names

[ CAS No. ]:
1217616-61-9

[ Name ]:
TSHR antagonist S37

Biological Activity

[Description]:

TSHR antagonist S37 is a selective and competitive thyrotropin receptor (TSHR) antagonist. TSHR antagonist S37 is the racemate of TSHR antagonist S37a[1].

[Related Catalog]:

Research Areas >> Endocrinology
Signaling Pathways >> GPCR/G Protein >> TSH Receptor

[Target]

TSHR[1]


[In Vitro]

TSHR antagonist S37 reduces also cAMP activation induced by the small molecule agonist C2[1]. TSHR antagonist S37 (10-100 µM) does not affect cell viability in the concentration range for the Hek293T-TSHR cell line[1].

[References]

[1]. Marcinkowski P, et al. A New Highly Thyrotropin Receptor-Selective Small-Molecule Antagonist with Potential for the Treatment of Graves' Orbitopathy. Thyroid. 2019 Jan;29(1):111-123.

Chemical & Physical Properties

[ Molecular Formula ]:
C25H20N2O3S2

[ Molecular Weight ]:
460.57

Related Compounds