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Thalidomide D4

Names

[ CAS No. ]:
1219177-18-0

[ Name ]:
Thalidomide D4

[Synonym ]:
|A-Phthalimidoglutarimide-d4
Myrin-d4
3-Phthalimidoglutarimide-d4
Celgene-d4
Contergan-d4
Thalidomide-d4
Distaval-d4
Kevadon-d4

Biological Activity

[Description]:

Thalidomide D4 is a deuterium labeled Thalidomide. Thalidomide is initially promoted as a sedative, inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of ~250 nM, and has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties[1][2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer
Signaling Pathways >> Autophagy >> Autophagy
Research Areas >> Inflammation/Immunology
Signaling Pathways >> PROTAC >> Ligand for E3 Ligase

[Target]

Kd: ~250 nM (CRL4CRBN)[1]


[References]

[1]. Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512(7512):49-53.

[2]. Sun X, et al. Synergistic Inhibition of Thalidomide and Icotinib on Human Non-Small Cell Lung Carcinomas Through ERK and AKT Signaling. Med Sci Monit. 2018 May 15;24:3193-3203.

Chemical & Physical Properties

[ Molecular Formula ]:
C13H6D4N2O4

[ Molecular Weight ]:
262.25400

[ Exact Mass ]:
262.08900

[ PSA ]:
87.04000

[ LogP ]:
0.30160

Related Compounds