Cetalkonium chloride

Names

[ CAS No. ]:
122-18-9

[ Name ]:
Cetalkonium chloride

[Synonym ]:
N-hexadecyl-N,N-dimethyl-N-benzylammonium chloride
dimethylbenzylhexadecylammonium chloride
Cetyldimethylbenzylammonium
hexadecyldimethylbenzylammonium chloride
EINECS 204-526-3
Acquat CDAC
acinol
Cetol
Cetylbenzyldimethylammonium chloride
benzyl-dimethyl-cetylammonium chloride
MFCD00011625
benzyl-dimethyl-hexadecyl-ammonium chloride
dmcbac
CKC
benzyl-n-hexadecyldimethyl ammonium chloride
Cetalkonium chloride
N-Benzyl-N,N-dimethylhexadecan-1-aminium chloride
16-BAC,Benzylhexadecyldimet
cdbac
Cetyldimethylbenzylammonium chloride
Ammonyx T
banicol
Benzylhexadecyldimethylammonium Chloride Hydrate
Benzylcetyldimethylammonium Chloride Hydrate
N-Benzyl-N,N-dimethyl-1-hexadecanaminium chloride
win357
Acetoquat CDAC
spilan
Benzyldimethyl-n-hexadecylammonium chloride
benzylhexadecyldimethylammonium chloride
Benzenemethanaminium, N-hexadecyl-N,N-dimethyl-, chloride (1:1)
Zettyn
cetylon
bonjela
Ammonyx G
HDBAC
Benzyldimethylhexadecylammonium Chloride Hydrate

Biological Activity

[Description]:

Cetalkonium chloride is an ammonium antiseptic agent used in many topical drugs for infections of mouth, throat and eye. Cetalkonium chloride acts as anti-inflammatory amphiphilic agent[1].

[Related Catalog]:

Research Areas >> Infection

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Cesar Torres-Luna, et al. Formation of Drug-Participating Catanionic Aggregates for Extended Delivery of Non-Steroidal Anti-Inflammatory Drugs from Contact Lenses. Biomolecules. 2019 Oct 10;9(10):593.

Chemical & Physical Properties

[ Melting Point ]:
55-65 °C(lit.)

[ Molecular Formula ]:
C₂₅H₄₆ClN

[ Molecular Weight ]:
396.092

[ Exact Mass ]:
395.331879

[ LogP ]:
4.74830

[ Water Solubility ]:
MODERATELY SOLUBLE

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BO6822450

CHEMICAL NAME :: Ammonium, benzyldimethylhexadecyl-, chloride

CAS REGISTRY NUMBER :: 122-18-9

LAST UPDATED :: 199710

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C25-H46-N.Cl

MOLECULAR WEIGHT :: 396.17

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 9,349,1959

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - guinea pig

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 9,349,1959 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NCNSA6 National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. (Washington, DC) Volume(issue)/page/year: 5,39,1953 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9945 No. of Facilities: 386 (estimated) No. of Industries: 9 No. of Occupations: 10 No. of Employees: 5332 (estimated) No. of Female Employees: 389 (estimated)

Safety Information

[ Symbol ]:

GHS05, GHS07, GHS09

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302 + H312-H314-H400

[ Precautionary Statements ]:
P273-P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
C:Corrosive;N:Dangerousfortheenvironment;

[ Risk Phrases ]:
R21/22;R34;R50

[ Safety Phrases ]:
S61-S45-S36/37/39-S26

[ RIDADR ]:
UN 3077 9/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
BO6822450

[ Hazard Class ]:
9.0

[ HS Code ]:
2923900090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2923900090

[ Summary ]:
2923900090 other quaternary ammonium salts and hydroxides。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Articles

Effect of the cationic surfactant moiety on the structure of water entrapped in two catanionic reverse micelles created from ionic liquid-like surfactants.

ChemPhysChem 15(14) , 3097-109, (2014)

The behavior of water entrapped in reverse micelles (RMs) formed by two catanionic ionic liquid-like surfactants, benzyl-n-hexadecyldimethylammonium 1,4-bis-2-ethylhexylsulfosuccinate (AOT-BHD) and ce...

Characterization of antibiotic and disinfectant susceptibility profiles among Pseudomonas aeruginosa veterinary isolates recovered during 1994-2003.

J. Appl. Microbiol. 118(2) , 326-42, (2015)

To evaluate susceptibility of Pseudomonas aeruginosa veterinary isolates to antibiotics and disinfectants.Pseudomonas aeruginosa isolates collected from dogs (n = 155) and other animals (n = 20) from ...

Determination of quaternary ammonium compounds in oranges and cucumbers using QuEChERS extraction and ultra-performance liquid chromatography/tandem mass spectrometry.

J. AOAC Int. 97(4) , 1021-6, (2014)

A simple and fast method has been developed for determining relevant quaternary ammonium compounds in cucumber and orange samples. The target compounds were benzoalkonium chloride (BAC-10, BAC-12, BAC...