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Propargyl-PEG1-NH2

Names

[ CAS No. ]:
122116-12-5

[ Name ]:
Propargyl-PEG1-NH2

Biological Activity

[Description]:

Propargyl-PEG1-NH2 is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Molecular Formula ]:
C5H9NO

[ Molecular Weight ]:
99.13110

[ Flash Point ]:
50 °C

[ Exact Mass ]:
99.06840

[ PSA ]:
35.25000

[ LogP ]:
0.29520

[ Index of Refraction ]:
1.45

Precursor & DownStream

Precursor

DownStream

Related Compounds