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Gymnemic acid I

Names

[ CAS No. ]:
122168-40-5

[ Name ]:
Gymnemic acid I

[Synonym ]:
(3β,16β,21β,22α)-28-Acetoxy-16,22,23-trihydroxy-21-{[(2E)-2-methylbut-2-enoyl]oxy}olean-12-en-3-yl β-D-glucopyranosiduronic acid
gymnemic acid I
2-Butenoic acid, 2-methyl-, (3β,16β,21β,22α)-28-(acetyloxy)-3-(β-D-glucopyranuronosyloxy)-16,22,23-trihydroxyolean-12-en-21-yl ester, (2E)-
(3β,16β,21β,22α)-28-Acetoxy-16,22,23-trihydroxy-21-{[(2E)-2-methyl-2-butenoyl]oxy}olean-12-en-3-yl β-D-glucopyranosiduronic acid

Biological Activity

[Description]:

Gymnemic acid I is a bioactive triterpene saponin found in Gymnema sylvestre. Gymnemic acid I decreases the apoptosis under the high glucose stress[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Metabolic Disease

[References]

[1]. Capolupo A, et al. Determination of Gymnemic Acid I as a Protein Biosynthesis Inhibitor Using Chemical Proteomics. J Nat Prod. 2017 Apr 28;80(4):909-915.

[2]. Wu Y, et al. Gymnemic acid I triggers mechanistic target of rapamycin-mediated β cells cytoprotection through the promotion of autophagy under high glucose stress. J Cell Physiol. 2019 Jun;234(6):9370-9377.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
872.1±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C43H66O14

[ Molecular Weight ]:
806.976

[ Flash Point ]:
252.8±27.8 °C

[ Exact Mass ]:
806.445251

[ PSA ]:
229.74000

[ LogP ]:
4.74

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.596

Related Compounds