Antifreeze Polypeptide 6 (winter flounder) trifluoroacetate salt

Names

[ Name ]:
Antifreeze Polypeptide 6 (winter flounder) trifluoroacetate salt

[Synonym ]:
L-Arginine, L-α-aspartyl-L-threonyl-L-alanyl-L-seryl-L-α-aspartyl-L-alanyl-L-alanyl-L-alanyl-L-alanyl-L-alanyl-L-alanyl-L-leucyl-L-threonyl-L-alanyl-L-alanyl-L-asparaginyl-L-alanyl-L-lysyl-L-a lanyl-L-alanyl-L-alanyl-L-α-glutamyl-L-leucyl-L-threonyl-L-alanyl-L-alanyl-L-asparaginyl-L-alanyl-L-alanyl-L-alanyl-L-alanyl-L-alanyl-L-alanyl-L-alanyl-L-threonyl-L-alanyl-
L-α-Aspartyl-L-threonyl-L-alanyl-L-seryl-L-α-aspartyl-L-alanyl-L-alanyl-L-alanyl-L-alanyl-L-alanyl-L-alanyl-L-leucyl-L-threonyl-L-alanyl-L-alanyl-L-asparaginyl-L-alanyl-L-lysyl-L-alanyl-L-alan yl-L-alanyl-L-α-glutamyl-L-leucyl-L-threonyl-L-alanyl-L-alanyl-L-asparaginyl-L-alanyl-L-alanyl-L-alanyl-L-alanyl-L-alanyl-L-alanyl-L-alanyl-L-threonyl-L-alanyl-L-arginine

Biological Activity

[Description]:

Antifreeze Polypeptide 6 (winter flounder) is the component 6 of the winter flounder's antifreeze polypeptides. Antifreeze Polypeptide 6 (winter flounder) lowers the plasma freezing point by arresting the growth of ice nuclei[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

Antifreeze Polypeptide 6 (winter flounder) inhibits the growth of ice crystals by hydrogen bonding of Thr, Asn, and Asp side chains in a specific pattern to the hexagonal bipyramidal planes of ice. This mode of binding is unidirectional, maximizing opportunities for packing of AFPs on the ice surface, and that ice crystal growth inhibition occurs by a two-step mechanism involving hydrogen bonding and hydrophobic interpeptide interactions[1].

[References]

[1]. Wen D, et al. A model for binding of an antifreeze polypeptide to ice. Biophys J. 1992 Dec;63(6):1659-62.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Molecular Formula ]:
C₁₃₃H₂₂₅N₄₃O₅₁

[ Molecular Weight ]:
3242.467

[ Exact Mass ]:
3240.633545

[ LogP ]:
-12.23

[ Index of Refraction ]:
1.648