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AZD3839

Names

[ CAS No. ]:
1227163-56-5

[ Name ]:
AZD3839

[Synonym ]:
4-Fluoro-1-(3-(pyrimidin-5-yl)phenyl)-1-(2-(trifluoromethyl)pyridin-4-yl)-1H-isoindol-3-amine
AZD3839

Biological Activity

[Description]:

(Rac)-AZD3839 is an orally active beta-amyloid precursor protein cleaving enzyme (BACE1) inhibitor that is blood-brain barrier-permeable. (Rac)-AZD3839 has an affinity for the human ether-a-go-go related gene (hERG) ion channel. (Rac)-AZD3839 can be used in the research of Alzheimer's disease[1].

[Related Catalog]:

Research Areas >> Neurological Disease
Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

[References]

[1]. Britt-Marie Swahn, et, al. Design and synthesis of β-site amyloid precursor protein cleaving enzyme (BACE1) inhibitors with in vivo brain reduction of β-amyloid peptides. J Med Chem2012, 55, 21.  

Chemical & Physical Properties

[ Molecular Formula ]:
C24H15F4N5

[ Molecular Weight ]:
449.40

[ Exact Mass ]:
449.12600

[ PSA ]:
77.05000

[ LogP ]:
4.84320

[ Storage condition ]:
-20℃

Related Compounds