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AZD3839

Names

[ CAS No. ]:
1227163-84-9

[ Name ]:
AZD3839

[Synonym ]:
1H-Isoindol-3-amine, 1-[2-(difluoromethyl)-4-pyridinyl]-4-fluoro-1-[3-(5-pyrimidinyl)phenyl]-, (1S)-
(1S)-1-(2-(Difluoromethyl)pyridin-4-yl)-4-fluoro-1-(3-(pyrimidin-5-yl)phenyl)-1H-isoindol-3-amine
AZD3839
(S)-1-(2-(difluoromethyl)pyridin-4-yl)-4-fluoro-1-(3-(pyrimidin-5-yl)phenyl)-1H-isoindol-3-amine
1H-Isoindol-3-amine, 1-(2-(difluoromethyl)-4-pyridinyl)-4-fluoro-1-(3-(5-pyrimidinyl)phenyl)-, (1S)-
(1S)-1-[2-(Difluoromethyl)-4-pyridinyl]-4-fluoro-1-[3-(5-pyrimidinyl)phenyl]-1H-isoindol-3-amine
AZD 3839
AZD3839 (free base)

Biological Activity

[Description]:

AZD3839 (free base) is a potent and selective BACE1 inhibitor with IC50 of 23.6 uM, about 14-fold selectivity over BACE2, also a β-secretase enzyme inhibitor.target: BACE1, β-secretase enzyme [1]IC50: 23.6 uM [1]AZD3839 dissolved in 0.33% dimethylsulfoxideIn vitro: AZD3839 and its metabolites M1 and M2 inhibited CYP3A4 in a reversible and an irreversible manner, which could affect not only the metabolism of other CYP3A4 substrates but also the metabolism of AZD3839 itself. [1]In vivo: AZD3839 is dissolved in 0.3 M gluconic acid, adjusted to pH 3. Solutions of 0.75, 2.5, and 7.5 mg/ml are prepared and are administered orally by gavage at 2 ml/kg body weight at 1.5, 5, and 15 mg/kg (study 1) and 15 mg/kg (study 2). [1]AZD3839 effectively reduces the levels of Aβ in brain, CSF, and plasma in several preclinical species. [2]

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Beta-secretase
Research Areas >> Cancer

[References]

[1]. Sparve E et al. Prediction and modeling of effects on the QTc interval for clinical safety margin assessment, based on single-ascending-dose study data with AZD3839. J Pharmacol Exp Ther. 2014 Aug;350(2):469-78.

[2]. Jeppsson F et al. Discovery of AZD3839, a potent and selective BACE1 inhibitor clinical candidate for the treatment of Alzheimer disease. J Biol Chem. 2012 Nov 30;287(49):41245-57.


[Related Small Molecules]

MK-8931 | LY2886721 | AZD3293(Lanabecestat) | LY2811376 | Epiberberine chloride | LX-2343 | PF-06751979 | Sophoflavescenol | BACE-IN-1 | BACE1-IN-1 | β-Secretase Inhibitor IV

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
596.3±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C24H16F3N5

[ Molecular Weight ]:
431.413

[ Flash Point ]:
314.4±32.9 °C

[ Exact Mass ]:
431.135773

[ PSA ]:
77.05000

[ LogP ]:
1.35

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.674

[ Storage condition ]:
-20℃

Related Compounds