2-Methylthio-AMP diTEA
Names
[ CAS No. ]:
1227193-98-7
[ Name ]:
2-Methylthio-AMP diTEA
Biological Activity
[Description]:
2-Methylthio-AMP (2-MeSAMP) diTEA is a selective and direct P2Y12 antagonist. 2-Methylthio-AMP diTEA is an inhibitor of ADP-dependent platelet aggregation[1][2][3].
[Related Catalog]:
[Target]
P2Y12[1]
[In Vitro]
2-Methylthio-AMP (2-MeSAMP) diTEA inhibits agonist-mediated αIIbβ3 activation in platelets[1]. 2-methylthio-AMP (50 μM; for 5 minutes) diTEA does not significantly inhibit thrombin, PAR1-AP, PAR4-AP, or ADP-mediated platelet Ca2+ mobilization. 2-methylthio-AMP diTEA fails to inhibit Ca2+ mobilization in P2Y12-deficient mouse platelets and does not raise cAMP or induce vasodilator-stimulated phosphoprotein phosphorylation in wild-type platelets[1].
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C23H46N7O7PS
[ Molecular Weight ]:
595.69