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BI-4464

Names

[ CAS No. ]:
1227948-02-8

[ Name ]:
BI-4464

Biological Activity

[Description]:

BI-4464 is a highly selective ATP competitive inhibitor of PTK2/FAK, with an IC50 of 17 nM. A PTK2 ligand for PROTAC[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FAK

[Target]

IC50: 17 nM (PTK2/FAK)[1].

[References]

[1]. Popow J, et al. Highly Selective PTK2 Proteolysis Targeting Chimeras to Probe Focal Adhesion Kinase Scaffolding Functions. J Med Chem. 2019 Mar 14;62(5):2508-2520.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₈H₂₈F₃N₅O₄

[ Molecular Weight ]:
555.55

[ Storage condition ]:
2-8℃

Related Compounds