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dm1-smcc

Names

[ CAS No. ]:
1228105-51-8

[ Name ]:
dm1-smcc

[Synonym ]:
dm1-smcc
N2'-Deacetyl-N2'-[3-[[1-[[4-[[(2,5-dioxo-1-pyrrolidinyl)oxy]carbonyl]cyclohexyl]methyl]-2,5-dioxo-3-pyrrolidinyl]thio]-1-oxopropyl]-maytansine

Biological Activity

[Description]:

SMCC-DM1 is DM1 with a reactive linker SMCC to make antibody drug conjugate. DM1 (mertansine), a thiol-containing maytansinoid, is a potent microtubule-disrupting agent.

[Related Catalog]:

Signaling Pathways >> Antibody-drug Conjugate >> Drug-Linker Conjugates for ADC
Research Areas >> Cancer

[Related Small Molecules]

VcMMAE | Mertansine | McMMAF | Val-Cit-PAB-MMAE | Mc-MMAE | Acetylene-linker-Val-Cit-PABC-MMAE | Deruxtecan analog | SPDB-DM4 | Fmoc-Val-Cit-PAB-MMAE | Mc-MMAD | sulfo-SPDB-DM4

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C51H66ClN5O16S

[ Molecular Weight ]:
1072.612

[ Exact Mass ]:
1071.391357

[ PSA ]:
282.83000

[ LogP ]:
3.28

[ Index of Refraction ]:
1.626

[ Storage condition ]:
2-8℃

Related Compounds