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Modipafant

Names

[ CAS No. ]:
122957-06-6

[ Name ]:
Modipafant

[Synonym ]:
Modipafant
QCR-95
UNII-1DMI0E5023

Biological Activity

[Description]:

Modipafant (UK-80067), the (+)-enantiomer of UK-74505, is a potent, orally active, and selective platelet-activating factor (PAF) antagonist. Modipafant exhibits approximately double the intrinsic potency of UK-74505[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Inflammation/Immunology

[In Vitro]

when preincubated with rabbit platelets, the potency of antagonizing PAF induced aggregation increased markedly when preincubation time with Modipafant was increased from 2 min (IC50=5.6 nM) to 60 min (IC50=0.34 nM)[2].

[References]

[1]. Kuitert LM, et al. Effect of a novel potent platelet-activating factor antagonist, modipafant, in clinical asthma. Am J Respir Crit Care Med. 1995;151(5):1331-1335.

[2]. Jezequel SG, et al, a new PAF antagonist: pharmacokinetics and disposition in rat, dog and man. Xenobiotica. 1996;26(9):963-975.

Chemical & Physical Properties

[ Density]:
1.34g/cm3

[ Molecular Formula ]:
C34H29ClN6O3

[ Molecular Weight ]:
605.08500

[ Exact Mass ]:
604.19900

[ PSA ]:
111.03000

[ LogP ]:
6.75300

Related Compounds