Choline Hydroxide

Names

[ CAS No. ]:
123-41-1

[ Name ]:
Choline Hydroxide

[Synonym ]:
Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, hydroxide (1:1)
Bursine
Gossypine
Sincaline
VIDINE
MFCD00002831
EINECS 204-625-1
2-Hydroxy-N,N,N-trimethylethanaminium hydroxide
Luridine
Fagine
Choline hydroxide
UNII:7THJ3EG9SY

Biological Activity

[Description]:

Choline hydroxide is a Choline hydrogen oxidized derivative and a strong organic base, can be used as the standard alkaline to adjust the pH of the medium. Choline is an orally active nutrient, serves as an important component of lecithin and sphingomyelin, promotes fat metabolism [1][2][3].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

Choline hydroxide can be used as the standard alkaline, and (0.5 M) results pHo shifts rapidly to 7.59 in a sucrose medium (pH at 7.08)[1]. Choline hydroxide (0.1-0.5 g/mL), together with organic carboxylic acids, makes preparation of ionic liquids, which is used for prepare a ionic liquid-reverse micelle drug-carrying delivery system and involves in epidermal desensitization research[2].

[References]

[1]. Mitchell P, et al. Estimation of membrane potential and pH difference across the cristae membrane of rat liver mitochondria. Eur J Biochem. 1969 Feb;7(4):471-84.

[2]. Ding Y, et al. An ionic liquid-reverse micelle drug delivery system for epidermal desensitization therapy and its preparation method and application: China, CN113975224. 2022-01-28.

[3]. Wang F, et al. Short communication: Effects of dietary deoiled soy lecithin supplementation on circulating choline and choline metabolites, and the plasma phospholipid profile in Holstein cows fed palm fat. J Dairy Sci. 2021 Feb;104(2):1838-1845.

Chemical & Physical Properties

[ Density]:
1.09 g/mL at 20 °C

[ Molecular Formula ]:
C₅H₁₅NO₂

[ Molecular Weight ]:
121.178

[ Flash Point ]:
92 °F

[ Exact Mass ]:
121.110275

[ PSA ]:
43.29000

[ Index of Refraction ]:
n20/D 1.4304

[ Storage condition ]:
2-8°C

[ Stability ]:
Stable. Combustible. Incompatible with strong oxidizing agents.

[ Water Solubility ]:
miscible

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GA4025500

CHEMICAL NAME :: Choline hydroxide

CAS REGISTRY NUMBER :: 123-41-1

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C5-H14-N-O.H-O

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 21400 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 23,1357,1968 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1710 No. of Facilities: 31 (estimated) No. of Industries: 1 No. of Occupations: 16 No. of Employees: 11518 (estimated) No. of Female Employees: 5852 (estimated)

Safety Information

[ Hazard Codes ]:
C:Corrosive;

[ Risk Phrases ]:
R35

[ Safety Phrases ]:
S26-S36/37/39-S45

[ RIDADR ]:
UN 3286 3/PG 2

[ WGK Germany ]:
1

[ RTECS ]:
GA4025500

[ Packaging Group ]:
II

[ Hazard Class ]:
8

[ HS Code ]:
2923900090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2923900090

[ Summary ]:
2923900090 other quaternary ammonium salts and hydroxides。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%