[3-(quinolin-2-ylmethoxy)phenyl]methanol

Names

[ CAS No. ]:
123226-28-8

[ Name ]:
[3-(quinolin-2-ylmethoxy)phenyl]methanol

[Synonym ]:
3-(2-quinolinylmethyloxy)benzyl alcohol
2-(3-hydroxymethylphenoxy)methylquinoline
3-(2-quinolinylmethoxy)benzyl alcohol
3-(quinol-2-ylmethoxy)benzyl alcohol
3-(Quinolin-2-ylmethoxy)benzyl alcohol
[3-(quinolin-2-ylmethoxy)-phenyl]-methanol
Benzenemethanol,3-(2-quinolinylmethoxy)

Biological Activity

[Description]:

CAY10789 (compound 6) is a potent CysLT1R (cysteinyl leukotriene receptor 1) antagonist (IC50=2.80 μM) and GPBAR1 (G-protein-coupled bile acid receptor 1) agonist (EC50=3 μM). CAY10789 significantly reduces the adhesion of U937 cells to HAEC, reduces the expression of TNF-α. CAY10789 shows very promising metabolic stability and excellent pharmacokinetics. CAY10789 can be used for the research of colitis, metabolic syndromes, and other GPBAR1/CysLT1R-related diseases[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Leukotriene Receptor
Signaling Pathways >> GPCR/G Protein >> GPCR19
Research Areas >> Inflammation/Immunology
Research Areas >> Metabolic Disease

[Target]

CysLT1:2.80 ± 0.3 μM (IC50)

TNF-α


[References]

[1]. Fiorillo B, et al. Structural Basis for Developing Multitarget Compounds Acting on Cysteinyl Leukotriene Receptor 1 and G-Protein-Coupled Bile Acid Receptor 1. J Med Chem. 2021 Nov 25;64(22):16512-16529.

Chemical & Physical Properties

[ Molecular Formula ]:
C17H15NO2

[ Molecular Weight ]:
265.30700

[ Exact Mass ]:
265.11000

[ PSA ]:
42.35000

[ LogP ]:
3.30610

Related Compounds