ethyl 4-(4-hydroxy-3-methoxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Names

[ Name ]:
ethyl 4-(4-hydroxy-3-methoxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

[Synonym ]:
1,2,3,4-tetrahydro-3-quinolinamine
3-amino-1,2,3,4-tetrahydroquinoline
1,2,3,4-tetrahydroquinoline-3-amine

Biological Activity

[Description]:

gp120-IN-2 (compound 4i) is a potent HIV-1 gp120 inhibitor with an IC50 of 7.5 µM and CC50 of 112.93 µM. gp120-IN-2 shows anti-HIV-1 activity. gp120-IN-2 shows cytotoxicity in a dose dependent manner in SUP-T1 cells[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HIV

Research Areas >> Inflammation/Immunology

[Target]

HIV-1:7.5 μM (IC50)

HIV-1:112.93 μM (CC50)

[References]

[1]. Senapathi J, et al. Design, Synthesis, and Antiviral activity of 1,2,3,4-Tetrahydropyrimidine derivatives acting as novel entry inhibitors to target at "Phe43 cavity" of HIV-1 gp120. Bioorg Med Chem. 2021 Dec 15;52:116526.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₅H₁₈N₂O₅

[ Molecular Weight ]:
306.31

[ Exact Mass ]:
306.12200

[ PSA ]:
96.89000

[ LogP ]:
2.24940

ethyl 4-(4-hydroxy-3-methoxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream