NH-bis(m-PEG4)

Names

[ Name ]:
NH-bis(m-PEG4)

[Synonym ]:
N,N-bis(tetraethyleneglycol-monomethylether)amine
N,N-bis(tetraoxyethylenemonomethyl ether)amine
2,5,8,11-Tetraoxatridecan-13-amine,N-3,6,9,12-tetraoxatridec-1-yl
bis-[2-[2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy]-ethyl]-amine

Biological Activity

[Description]:

NH-bis(m-PEG4) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₃₉NO₈

[ Molecular Weight ]:
397.50400

[ Exact Mass ]:
397.26800

[ PSA ]:
85.87000

[ LogP ]:
0.35930

NH-bis(m-PEG4)

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds