Eprinomectin

Names

[ Name ]:
Eprinomectin

[Synonym ]:
(4''R)-4''-(Acetylamino)-4''-deoxyavermectin B1
(1'R,2S,4'S,5S,6R,8'R,10'E,12'S,13'S,14'E,16'E,20'R,21'R,24'S)-21',24'-Dihydroxy-6-isopropyl-5,11',13',22'-tetramethyl-2'-oxo-5,6-dihydrospiro[pyran-2,6'-[3,7,19]trioxatetracyclo[15.6.1.1.0]pentacosa[10,14,16,22]tetraen]-12'-yl 4-O-(4-acetamido-2,4,6-trideoxy-3-O-methyl-α-L-lyxo-hexopyranosyl)-2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranoside - (1'R,2S,4'S,5S,6R,8'R,10'E,12'S,1 3'S,14'E,16'E,20'R,21'R,24'S)-6-[(2S)-2-buta
Eprinomectin
Eprinex
EINECS 200-835-2
MFCD07370747

Biological Activity

[Description]:

Eprinomectin(MK-397) is an avermectin selected for development as a topical endectocide; has anthelmintic, insecticidal and miticidal activity.

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Parasite

Research Areas >> Infection

[References]

[1]. Baoliang P, et al. Pharmacokinetics of eprinomectin in plasma and milk following subcutaneous administration to lactating dairy cattle. Vet Res Commun. 2006 Apr;30(3):263-70.

[2]. Visser M, et al. The treatment of bovine sarcoptic mange (Sarcoptes scabiei var. bovis) using eprinomectin extended-release injection. Vet Parasitol. 2013 Mar 1;192(4):359-64.

[3]. Shoop WL, et al. Eprinomectin: a novel avermectin for use as a topical endectocide for cattle. Int J Parasitol. 1996 Nov;26(11):1237-42.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.23

[ Melting Point ]:
163-166 ºC

[ Molecular Formula ]:
C₅₀H₇₅NO₁₄

[ Molecular Weight ]:
914.13

[ Flash Point ]:
2 °C

[ PSA ]:
178.93000

[ LogP ]:
5.46970

[ Storage condition ]:
2-8°C

Safety Information

[ Symbol ]:

GHS06, GHS08, GHS09

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H361-H400

[ Precautionary Statements ]:
P273-P281-P301 + P310

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ Hazard Codes ]:
F,Xn,N,T

[ Risk Phrases ]:
11-20/21/22-36-62-50/53-25-63

[ Safety Phrases ]:
26-36/37-16-61-60-45

[ RIDADR ]:
UN 2811

[ WGK Germany ]:
3

Articles

Efficacy of a novel topical combination of fipronil, (S)-methoprene, eprinomectin, and praziquantel, against the ticks, Ixodes ricinus and Ixodes scapularis, on cats.

Vet. Parasitol. 202(1-2) , 59-63, (2014)

Five controlled, blinded and randomized studies were conducted to examine the efficacy of a single topical application of a combination of fipronil, (S)-methoprene, eprinomectin, and praziquantel (BRO...

Efficacy of a single dose of a novel topical combination product containing eprinomectin to prevent heartworm infection in cats

Vet. Parasitol. 202(1-2) , 49-53, (2014)

Cats may be infected by heartworm, Dirofilaria immitis, through mosquito bites. They can develop severe heartworm disease when infective D. immitis larvae migrate and develop into adults in the pulmon...

Efficacy of a novel topical combination of fipronil, (S)-methoprene, eprinomectin and praziquantel against experimental infections ofToxascaris leoninain cats

Vet. Parasitol. 202(1-2) , 40-4, (2014)

The efficacy of a novel topical fipronil, (S)-methoprene, eprinomectin and praziquantel combination product (BROADLINE®, Merial) was evaluated against adult Toxascaris leonina ascarids in experimental...