2-Amino-2-methyl-1-propanol
Names
[ CAS No. ]:
124-68-5
[ Name ]:
2-Amino-2-methyl-1-propanol
[Synonym ]:
2-Amino-2-methyl-1-propanol
2,2-Dimethyl-ethanolamine
EINECS 204-709-8
2-Amino-2-methyl-propan-1-ol
2-Amino-2-Methylpropan-1-Ol
MFCD00008051
Aminomethyl propanol
1,1-Dimethyl-2-hydroxyethylamine
1-Propanol, 2-amino-2-methyl-
Biological Activity
[Description]:
[Related Catalog]:
[References]
Chemical & Physical Properties
[ Density]:
0.9±0.1 g/cm3
[ Boiling Point ]:
167.2±13.0 °C at 760 mmHg
[ Melting Point ]:
24-28 °C(lit.)
[ Molecular Formula ]:
C4H11NO
[ Molecular Weight ]:
89.14
[ Flash Point ]:
67.2±0.0 °C
[ Exact Mass ]:
89.084061
[ PSA ]:
46.25000
[ LogP ]:
-0.61
[ Vapour density ]:
3 (vs air)
[ Vapour Pressure ]:
0.6±0.7 mmHg at 25°C
[ Index of Refraction ]:
1.447
[ Storage condition ]:
Store at RT.
[ Stability ]:
Stable. Combustible. Incompatible with strong oxidizing agents. May present an explosion hazard if heated.
[ Water Solubility ]:
miscible
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UA5950000
- CHEMICAL NAME :
- 1-Propanol, 2-amino-2-methyl-
- CAS REGISTRY NUMBER :
- 124-68-5
- BEILSTEIN REFERENCE NO. :
- 0505979
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 11
- MOLECULAR FORMULA :
- C4-H11-N-O
- MOLECULAR WEIGHT :
- 89.16
- WISWESSER LINE NOTATION :
- ZX1&1&1Q
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2900 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 9(2),203,1990
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2150 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 9(2),203,1990
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 1 gm/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - coma Lungs, Thorax, or Respiration - respiratory stimulation
- REFERENCE :
- JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 22,315,1940 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 44800 mg/kg/8W-C
- TOXIC EFFECTS :
- Liver - other changes Skin and Appendages - hair Related to Chronic Data - death
- REFERENCE :
- JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 9(2),203,1990
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 230 ug/m3/4H/13W-I
- TOXIC EFFECTS :
- Cardiac - changes in heart weight Lungs, Thorax, or Respiration - changes in lung weight Related to Chronic Data - changes in uterine weight
- REFERENCE :
- JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 9(2),203,1990
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 11340 mg/kg/28D-C
- TOXIC EFFECTS :
- Behavioral - food intake (animal) Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases
- REFERENCE :
- JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 9(2),203,1990
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Primate - monkey
- DOSE/DURATION :
- 6 mg/m3/89D-I
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - respiratory depression Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 9(2),203,1990
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - hamster
- DOSE/DURATION :
- 100 mg/m3/4H/13W-I
- TOXIC EFFECTS :
- Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 9(2),203,1990 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M5222 No. of Facilities: 2958 (estimated) No. of Industries: 28 No. of Occupations: 44 No. of Employees: 24640 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M5222 No. of Facilities: 16965 (estimated) No. of Industries: 136 No. of Occupations: 94 No. of Employees: 219300 (estimated) No. of Female Employees: 54846 (estimated)
Safety Information
[ Symbol ]:
GHS05
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H315-H318-H412
[ Precautionary Statements ]:
P273-P280-P305 + P351 + P338 + P310
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves
[ Hazard Codes ]:
Xi:Irritant
[ Risk Phrases ]:
R36/38;R52/53
[ Safety Phrases ]:
S61
[ RIDADR ]:
2735
[ WGK Germany ]:
1
[ RTECS ]:
UA5950000
[ Packaging Group ]:
III
[ HS Code ]:
2922199090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2922199090
[ Summary ]:
2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
Articles
Bioconjug. Chem. 26(2) , 286-93, (2015)
Bone morphogenetic protein-2 (BMP-2) plays an important role in bone and cartilage formation and is of interest in regenerative medicine. Heparin can interact electrostatically with BMP-2 and thus has...
Differentially circulating miRNAs after recent osteoporotic fractures can influence osteogenic differentiation.Bone 79 , 43-51, (2015)
Osteoporosis is the consequence of altered bone metabolism resulting in the systemic reduction of bone strength and increased risk of fragility fractures. MicroRNAs (miRNAs) regulate gene expression o...
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.Toxicol. Mech. Methods 18 , 217-27, (2008)
ABSTRACT Drug-induced phospholipidosis (PL) is a condition characterized by the accumulation of phospholipids and drug in lysosomes, and is found in a variety of tissue types. PL is frequently manifes...