VU0364739

Names

[ CAS No. ]:
1244639-78-8

[ Name ]:
VU0364739

[Synonym ]:
N-(2-(1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5 ]decan-8-yl)ethyl)-2-naphthamide
N-(2-(1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)-2-naphthamide
N-[2-[1-(3-FLUOROPHENYL)-4-OXO-1,3,8-TRIAZASPIRO[4.5]DEC-8-YL]ETHYL]-2-NAPHTHALENECARBOXAMIDE

Biological Activity

[Description]:

VU0364739 is a selective PLD2 inhibitor (IC50: 22 nM). VU0364739 decreases cancer cell proliferation[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> Phospholipase

[Target]

PLD[1]


[References]

[1]. Lavieri RR, et al. Design, synthesis, and biological evaluation of halogenated N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)benzamides: discovery of an isoform-selective small molecule phospholipase D2 inhibitor. J Med Chem. 2010 Sep 23;53(18):6706-19.  

Chemical & Physical Properties

[ Molecular Formula ]:
C26H27FN4O2

[ Molecular Weight ]:
446.52

[ Exact Mass ]:
446.21200

[ PSA ]:
64.68000

[ LogP ]:
3.85980