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Propargyl-PEG4-C2-acid

Names

[ CAS No. ]:
1245823-51-1

[ Name ]:
Propargyl-PEG4-C2-acid

[Synonym ]:
3-(2-{2-[2-(2-prop-2-ynyloxyethoxy)ethoxy]ethoxy}ethoxy)propanoic acid
Alkyne-PEG5-acid
PROPARGYL-PEG5-ACID

Biological Activity

[Description]:

Propargyl-PEG5-acid is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG5-acid can used to synthesize ADC inhibitors of Galectin-3[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

[Target]

Non-cleavable


[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

[References]

[1]. Zhang H, et al. Thiodigalactoside-Bovine Serum Albumin Conjugates as High-Potency Inhibitors of Galectin-3: An Outstanding Example of Multivalent Presentation of Small Molecule Inhibitors. Bioconjug Chem. 2018 Apr 18;29(4):1266-1275.

Chemical & Physical Properties

[ Molecular Formula ]:
C14H24O7

[ Molecular Weight ]:
304.33600

[ Exact Mass ]:
304.15200

[ PSA ]:
83.45000

[ LogP ]:
0.17730

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H319

[ Precautionary Statements ]:
P305 + P351 + P338

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

Related Compounds