Teludipine-d6

Names

[ CAS No. ]:
1246833-02-2

[ Name ]:
Teludipine-d6

Biological Activity

[Description]:

Teludipine-d6 (GR53992B-d6) is the deuterium labeled Teludipine hydrochloride. Teludipine is a lipophilic calcium channel blocker[1][2].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel
Research Areas >> Cancer

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Tolomeo M, et al. Effects of R-enantiomer (GR66234A) and L-enantiomer (GR66235A) of telupidine, a new dihydropyridine derivative, on cell lines displaying the multidrug resistant phenotype. Haematologica. 1994 Jul-Aug;79(4):328-33.

Chemical & Physical Properties

[ Molecular Formula ]:
C28H32D6N2O6

[ Molecular Weight ]:
504.65

Related Compounds