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SPDP-dPEG

Names

[ CAS No. ]:
1252257-56-9

[ Name ]:
SPDP-dPEG

[Synonym ]:
Propanamide, N-[27-[(2,5-dioxo-1-pyrrolidinyl)oxy]-27-oxo-3,6,9,12,15,18,21,24-octaoxaheptacos-1-yl]-3-(2-pyridinyldithio)-
N-{27-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-27-oxo-3,6,9,12,15,18,21,24-octaoxaheptacos-1-yl}-3-(2-pyridinyldisulfanyl)propanamide

Biological Activity

[Description]:

LC-PEG8-SPDP is a cleavable ADC linker used for the antibody-drug conjugates (ADCs)[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

[Target]

Cleavable


[References]

[1]. Zhao RY, et al. Synthesis and evaluation of hydrophilic linkers for antibody-maytansinoid conjugates. J Med Chem. 2011 May 26;54(10):3606-23.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Molecular Formula ]:
C31H49N3O13S2

[ Molecular Weight ]:
735.863

[ Exact Mass ]:
735.270691

[ LogP ]:
-2.32

[ Index of Refraction ]:
1.555

Related Compounds