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L-156,602

Names

[ CAS No. ]:
125228-51-5

[ Name ]:
L-156,602

Biological Activity

[Description]:

L-156602 is a C5a receptor antagonist. L-156602 inhibits inflammation, and the migration of monocytes and neutrophils to the infiltrating site in mouse inflammatory models. L-156602 suppresses the efferent phase of delayed-type hypersensitivity (DTH)[1][2].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Complement System
Research Areas >> Inflammation/Immunology

[Target]

C5a receptor[1][2]


[References]

[1]. Tsuji RF, et al. Effects of L-156,602, a C5a receptor antagonist, on mouse experimental models of inflammation. Biosci Biotechnol Biochem. 1992 Dec;56(12):2034-6.  

[2]. Tsuji RF, et al. Anti-inflammatory effects and specificity of L-156,602: comparison of effects on concanavalin A and zymosan-induced footpad edema, and contact sensitivity response. Immunopharmacology. 1995 Feb;29(1):79-87.  

Chemical & Physical Properties

[ Molecular Formula ]:
C38H64N8O13

[ Molecular Weight ]:
840.96

[ Exact Mass ]:
840.45900

[ PSA ]:
279.95000

[ LogP ]:
0.19240

Related Compounds