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DBCO-PEG(4)-NH2

Names

[ CAS No. ]:
1255942-08-5

[ Name ]:
DBCO-PEG(4)-NH2

[Synonym ]:
3,6,9,12-Tetraoxapentadecan-15-amide, 1-amino-N-[3-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-3-oxopropyl]-
1-Amino-N-[3-(11,12-didehydrodibenzo[b,f]azocin-5(6H)-yl)-3-oxopropyl]-3,6,9,12-tetraoxapentadecan-15-amide

Biological Activity

[Description]:

DBCO-NHCO-PEG4-amine is a cleavable ADC linker used to conjugate MMAE (HY-15162) and antibody (e.g., DBCO-VCpAB−MMAE and DBCO-TRX−MMAE with EC50s of 280 nM and 22 nM in SKBR3 cells, respectively)[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

[Target]

Cleavable


[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

[References]

[1]. Spangler B, et al. Toward a Ferrous Iron-Cleavable Linker for Antibody-Drug Conjugates. Mol Pharm. 2018 May 7;15(5):2054-2059. .

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
784.1±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C29H37N3O6

[ Molecular Weight ]:
523.621

[ Flash Point ]:
428.0±32.9 °C

[ Exact Mass ]:
523.268250

[ LogP ]:
1.56

[ Vapour Pressure ]:
0.0±2.7 mmHg at 25°C

[ Index of Refraction ]:
1.595

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds