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(S)-Bepotastine

Names

[ CAS No. ]:
125602-71-3

[ Name ]:
(S)-Bepotastine

[Synonym ]:
(+)-(S)-4-[4-[(4-chlorophenyl)(2-pyridyl)methoxy]piperidino]butyric acid monobenzenesulfonate
4-[(S)-(4-chlorophenyl)-2-pyridinylMethoxy]
4-{4-[(S)-(4-Chlorophenyl)(2-pyridinyl)methoxy]-1-piperidinyl}butanoic acid
(+)-(S)-4-{4[(4-chlorphenyl)(2-pyridil)methoxy]piperidino}butyric acid monobenzenesulfonate
1-Piperidinebutanoic acid, 4-[(S)-(4-chlorophenyl)-2-pyridinylmethoxy]-
1-Piperidinebutanoic acid,4-[(S)-(4-chlorophenyl)-2-pyridinylmethoxy]
4-[4-[(4-Chlorophenyl)pyridin-2-ylmethoxy]piperidin-1-yl]butanoic acid
(+)-(S)-4-[4-[1-(4-chlorophenyl)-1-(2-pyridyl)methoxy]piperidin-1-yl]butyric acid
[14C]-Bepotastine besilate
Bepotastine
4-(4-[(1S)(4-CHLOROPHENYL)-2-PYRIDYLMETHOXY]PIPERIDYL)BUTANOIC ACID
betotastine besilate
4-(4-((S)-(4-Chlorophenyl)(pyridin-2-yl)methoxy)piperidin-1-yl)butanoic Acid
(+)-4-(((S)-p-Chloro-2-pyridylbenzyl)oxy)-1-piperidinebutyric Acid
betotastine
Bepreve
4-{4-[(S)-(4-Chlorophenyl)(pyridin-2-yl)methoxy]piperidin-1-yl}butanoic acid

Biological Activity

[Description]:

Bepotastine is an orally active second-generation histamine H1 receptor antagonist. Bepotastine has the potential for allergic rhinitis and urticaria/pruritus treatment[1][2].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor
Research Areas >> Endocrinology
Research Areas >> Inflammation/Immunology
Signaling Pathways >> GPCR/G Protein >> Histamine Receptor

[Target]

Histamine H1 receptor[1]


[References]

[1]. Kanzaki S, et al. Histamine antagonist Bepotastine suppresses nasal symptoms caused by Japanese cedar and cypress pollen exposure. J Drug Assess. 2016 Sep 27;5(1):15-23.

[2]. Singh DK, et al. Characterization of Photodegradation Products of Bepotastine Besilate and In silico Evaluation of Their Physicochemical, Absorption, Distribution, Metabolism, Excretion and Toxicity Properties. J Pharm Sci. 2020 Mar 12. pii: S0022-3549(20)30128-3.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
546.8±50.0 °C at 760 mmHg

[ Melting Point ]:
56-58 °C

[ Molecular Formula ]:
C21H25ClN2O3

[ Molecular Weight ]:
388.888

[ Flash Point ]:
284.5±30.1 °C

[ Exact Mass ]:
388.155365

[ PSA ]:
62.66000

[ LogP ]:
3.67

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.605

Safety Information

[ Hazard Codes ]:
Xn

Synthetic Route

Click to get detail synthetic route

Related Compounds