Fibronectin Adhesion-Promoting Peptide trifluoroacetate salt

Names

[ Name ]:
Fibronectin Adhesion-Promoting Peptide trifluoroacetate salt

[Synonym ]:
trp-gln-pro-pro-arg-ala-arg-ile
h-trp-gln-pro-pro-arg-ala-arg-ile-oh
heparin-binding peptide
wqpprari

Biological Activity

[Description]:

Heparin Binding Peptide is one of the heparin-binding amino acid sequences found in the carboxy-terminal heparin-binding domain of fibronectin.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Peptides

Research Areas >> Cardiovascular Disease

[In Vitro]

GRGDS and Heparin Binding Peptide (WQPPRARI peptide) micropatterns increase the endothelialisation of prosthetic materials in vitro. WQPPRARI peptide also enhances haptotactic cell migration. The anti-apoptotic effects of fibronectin require the presence of the WQPPRARI sequence, which may be due to synergistic survival signals mediated by this sequence and by the RGD motif[1]. RDGS and WQPPRARI peptides promote cell adhesion through different activation pathways that induce different forms of adhesion which can be highlighted through the analysis of focal and fibrillar contacts[2].

[References]

[1]. Hoesli CA, et al. A fluorophore-tagged RGD peptide to control endothelial cell adhesion to micropatterned surfaces. Biomaterials. 2014 Jan;35(3):879-90.

[2]. Chollet C, et al. Impact of peptide micropatterning on endothelial cell actin remodeling for cell alignment under shear stress. Macromol Biosci. 2012 Dec;12(12):1648-59.

[Related Small Molecules]

Chemical & Physical Properties

[ Molecular Formula ]:
C₄₇H₇₄N₁₆O₁₀

[ Molecular Weight ]:
1023.19000

[ Exact Mass ]:
1022.58000

[ PSA ]:
432.12000

[ LogP ]:
2.99910

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Articles

A synthetic peptide from the COOH-terminal heparin-binding domain of fibronectin promotes focal adhesion formation.

Mol. Biol. Cell 4 , 605, (1993)

Cell adhesion to extracellular matrix molecules such as fibronectin involves complex transmembrane signaling processes. Attachment and spreading of primary fibroblasts can be promoted by interactions ...