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gontivimab

Names

[ CAS No. ]:
1257358-38-5

[ Name ]:
gontivimab

Biological Activity

[Description]:

Gontivimab (ALX-0171; VR-465) is a poent anti-RSV prefusion F protein nanobody with a KD value of 0.113 nM. Gontivimab shows antiviral activity. Gontivimab reduces the RSV load in the nose and lung[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> RSV

[Target]

KD: 0.113 nM (RSV prefusion F protein)[1]


[In Vitro]

Gontivimab (0-100000 nM) 显示出抗病毒活性，对 RSV-A、RSV-B 18537 菌株的 IC50 分别为 0.1、0.4 nM[1]。 Gontivimab 与 F 蛋白的抗原位点 II 结合[1]。

[In Vivo]

Gontivimab (1-68 mg/kg；鼻内给药或雾化) 降低大鼠鼻腔和肺部的 RSV 负荷[1]。 Animal Model: Rats (RSV Tracy)[1] Dosage: 1-68 mg/kg Administration: Intranasal administration or nebulization; once (day 2 or day 3) or twice (day 2 and day 3) Result: Resulted in significant viral load reductions in the lungs ranging.

[References]

[1]. Detalle L, et al. Generation and Characterization of ALX-0171, a Potent Novel Therapeutic Nanobody for the Treatment of Respiratory Syncytial Virus Infection. Antimicrob Agents Chemother. 2015 Oct 5;60(1):6-13.  

Chemical & Physical Properties

No Any Chemical & Physical Properties

Related Compounds