CB2R-IN-1

CB2R-IN-1 is a potent cannabinoid CB2 receptor inverse agonist with a Ki of 0.9 nM.

Signaling Pathways >> GPCR/G Protein >> Cannabinoid Receptor

Research Areas >> Neurological Disease

CB2 Receptor:0.9 nM (Ki)

CB2R-IN-1 (Compound 37) is a potent cannabinoid CB2 receptor ligand (Ki=0.9 nM) with excellent selectivity over the CB1 receptor (Ki=8259.3 nM)[1].

[1]. Tong L, et al. Expansion of SAR studies on triaryl bis sulfone cannabinoid CB2 receptor ligands. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6785-9.

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