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Macitentan D4

Names

[ CAS No. ]:
1258428-05-5

[ Name ]:
Macitentan D4

[Synonym ]:
N-[5-(4-Bromophenyl)-6-({2-[(5-bromo-2-pyrimidinyl)oxy](H)ethyl}oxy)-4-pyrimidinyl]-N'-propylsulfuric diamide
Sulfamide, N-[5-(4-bromophenyl)-6-[[2-[(5-bromo-2-pyrimidinyl)oxy]ethyl-1,1,2,2-d]oxy]-4-pyrimidinyl]-N'-propyl-

Biological Activity

[Description]:

Macitentan D4 (ACT-064992 D4) is a deuterium labeled Sulfamethoxazole. Macitentan is an orally active, non-peptide dual ETA and ETB (endothelin) receptor antagonist. Macitentan is used for the potential treatment of idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH)[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cardiovascular Disease
Signaling Pathways >> GPCR/G Protein >> Endothelin Receptor

[Target]

ETA/ETB[1]


[References]

[1]. Corallo C, et al. Bosentan and macitentan prevent the endothelial-to-mesenchymal transition (EndoMT) in systemic sclerosis: in vitro study. Arthritis Res Ther. 2016 Oct 6;18(1):228.

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
692.4±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C19H16D4Br2N6O4S

[ Molecular Weight ]:
592.29800

[ Flash Point ]:
372.5±34.3 °C

[ Exact Mass ]:
589.98800

[ PSA ]:
136.60000

[ LogP ]:
5.41

[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C

[ Index of Refraction ]:
1.634

Related Compounds