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JP1302 dihydrochloride

Names

[ CAS No. ]:
1259314-65-2

[ Name ]:
JP1302 dihydrochloride

[Synonym ]:
N-[4-(4-Methyl-1-piperazinyl)phenyl]-9-acridinamine dihydrochloride
N-[4-(4-Methylpiperazin-1-yl)phenyl]acridin-9-amine dihydrochloride
9-Acridinamine, N-[4-(4-methyl-1-piperazinyl)phenyl]-, hydrochloride (1:2)

Biological Activity

[Description]:

JP1302 dihydrochloride is a selective, high affinity antagonist of the alpha2C-adrenoceptor (α2C-adrenoceptor), with a Kb value (antagonist activity) of 16 nM and a Ki (binding affinity) value of 28 nM[1][2].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor
Research Areas >> Neurological Disease

[Target]

Ki: 28 nM (α2C- adrenoceptor)[2]. Kb: 16 nM (α2C- adrenoceptor)[2].


[References]

[1]. Tricklebank MD, et al. JP-1302: a new tool to shed light on the roles of alpha2C-adrenoceptors in brain. Br J Pharmacol. 2007 Feb;150(4):381-2.

[2]. Sallinen J, et al. Pharmacological characterization and CNS effects of a novel highly selective alpha2C-adrenoceptor antagonist JP-1302. Br J Pharmacol. 2007 Feb;150(4):391-402.

Chemical & Physical Properties

[ Molecular Formula ]:
C24H26Cl2N4

[ Molecular Weight ]:
441.40

[ Exact Mass ]:
440.153442

Related Compounds