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NH2-PEG1-CH2CH2-Boc

Names

[ CAS No. ]:
1260092-46-3

[ Name ]:
NH2-PEG1-CH2CH2-Boc

[Synonym ]:
MFCD20727480
Propanoic acid, 3-(2-aminoethoxy)-, 1,1-dimethylethyl ester
2-Methyl-2-propanyl 3-(2-aminoethoxy)propanoate

Biological Activity

[Description]:

NH2-PEG1-CH2CH2-Boc is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Alkyl/ether


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. Qiu X, et al. Chemoselective Synthesis of Lenalidomide-Based PROTAC Library Using Alkylation Reaction. Org Lett. 2019 May 17;21(10):3838-3841.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
264.9±15.0 °C at 760 mmHg

[ Molecular Formula ]:
C9H19NO3

[ Molecular Weight ]:
189.252

[ Flash Point ]:
90.5±16.7 °C

[ Exact Mass ]:
189.136490

[ LogP ]:
0.84

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.445

Safety Information

[ Hazard Codes ]:
Xn

Related Compounds