N-methyl-N-(t-Boc)-PEG4-acid

Names

[ Name ]:
N-methyl-N-(t-Boc)-PEG4-acid

[Synonym ]:
2,2,5-Trimethyl-4-oxo-3,8,11,14,17-pentaoxa-5-azaicosan-20-oic acid
MFCD28950776
3,8,11,14,17-Pentaoxa-5-azaeicosan-20-oic acid, 2,2,5-trimethyl-4-oxo-

Biological Activity

[Description]:

N-Methyl-N-(t-Boc)-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Alkyl/ether

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
488.2±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₇H₃₃NO₈

[ Molecular Weight ]:
379.446

[ Flash Point ]:
249.1±28.7 °C

[ Exact Mass ]:
379.220612

[ LogP ]:
0.35

[ Vapour Pressure ]:
0.0±2.7 mmHg at 25°C

[ Index of Refraction ]:
1.470

N-methyl-N-(t-Boc)-PEG4-acid

Names

Biological Activity

Chemical & Physical Properties

Related Compounds