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JCP174

Names

[ CAS No. ]:
126062-19-9

[ Name ]:
JCP174

[Synonym ]:
7-Amino-4-chloro-3-propoxy-isocoumarin
MFCD22378306
1H-2-Benzopyran-1-one, 7-amino-4-chloro-3-propoxy-
7-Amino-4-chloro-3-propoxy-1H-isochromen-1-one

Biological Activity

[Description]:

JCP174 is an inhibitor of palmitoyl protein thioesterase-1 (TgPPT1), a depalmitoylase in the parasite T. gondii[1]. JCP174 is also an inhibitor of porcine pancreatic elastase and human leukocyte elastase[2][3].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Metabolic Enzyme/Protease >> Elastase

[References]

[1]. Child MA, et al. Small-molecule inhibition of a depalmitoylase enhances Toxoplasma host-cell invasion. Nat Chem Biol. 2013 Oct;9(10):651-6.

[2]. Powers JC, et al. Reaction of porcine pancreatic elastase with 7-substituted 3-alkoxy-4-chloroisocoumarins: design of potent inhibitors using the crystal structure of the complex formed with 4-chloro-3-ethoxy-7-guanidinoisocoumarin. Biochemistry. 1990 Mar 27;29(12):3108-18.

[3]. Kerrigan JE, et al. Mechanism-based isocoumarin inhibitors for human leukocyte elastase. Effect of the 7-amino substituent and 3-alkoxy group in 3-alkoxy-7-amino-4-chloroisocoumarins on inhibitory potency. J Med Chem. 1995 Feb 3;38(3):544-52.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
463.4±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C12H12ClNO3

[ Molecular Weight ]:
253.682

[ Flash Point ]:
234.1±28.7 °C

[ Exact Mass ]:
253.050568

[ LogP ]:
2.10

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.601

Related Compounds