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Siamenoside I

Names

[ CAS No. ]:
126105-12-2

[ Name ]:
Siamenoside I

[Synonym ]:
β-D-Glucopyranoside, (1R,4R)-4-[(3β,8α,9β,10α,11α,17β)-3-(β-D-glucopyranosyloxy)-11-hydroxy-4,4,9,14-tetramethylestr-5-en-17-yl]-1-(1-hydroxy-1-methylethyl)pentyl O-β-D-g&#xD; lucopyranosyl-(1->2)-O-[β-D-glucopyranosyl-(1->6)]-
β-D-glucopyranoside, (1R,4R)-4-[(3β,8α,9β,10α,11α,17β)-3-(β-D-glucopyranosyloxy)-11-hydroxy-4,4,9,14-tetramethylestr-5-en-17-yl]-1-(1-hydroxy-1-methylethyl)pentyl O-β-D-glucopyranosyl-(1->;2)-O-[β-D-glucopyranosyl-(1->6)]-
(1S,4R,8β,9β,11α,24R)-1-(β-D-Glucopyranosyloxy)-11,25-dihydroxy-9,10,14-trimethyl-4,9-cyclo-9,10-secocholest-5-en-24-yl β-D-glucopyranosyl-(1->2)-[β-D-glucopyranosyl-(1->6)]-β-D- &#xA;glucopyranoside
Siamenoside I
(1S,4R,8β,9β,11α,24R)-1-(β-D-Glucopyranosyloxy)-11,25-dihydroxy-9,10,14-trimethyl-4,9-cyclo-9,10-secocholest-5-en-24-yl β-D-glucopyranosyl-(1->2)-[β-D-glucopyranosyl-(1->6)]-β-D-glucopyranoside
SiamenosideI

Biological Activity

[Description]:

Siamenoside I is one of the mogrosides that has several kinds of bioactivities.

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Others
Natural Products >> Terpenoids and Glycosides

[In Vivo]

In rat, the metabolic reactions of siamenoside I include deglycosylation, hydroxylation, dehydrogenation, deoxygenation, isomerization, and glycosylation. Siamenoside I and its metabolites are mainly distributed to the intestines, stomach, kidneys, and brain[1].

[Animal admin]

The animal experiment lasts six days. The whole urine and feces of days 1-2 are collected as blank urine and feces samples, respectively. On days 3-5, the rats of test group are orally administrated with siamenoside I [50 mg/kg body weight, in normal saline (NS) solution] at 9:00, and all 72-h urine and feces are collected as drug-containing urine and feces samples, respectively. The rats of blank group are orally administrated with the same volume of NS. On day 6 at 9:00, the test and the blank group are treated with siamenoside I and NS again, respectively. After 1 h, blood sample is collected into a vacuum tube with sodium citrate as anticoagulant from rat heart under anesthesia. Then, the organs (heart, liver, spleen, lung, kidneys, stomach, small intestine, brain) and skeletal muscles of rats are collected and washed with NS, separately. All samples are kept at −80°C before further pretreatment.

[References]

[1]. Yang XR, et al. Metabolites of Siamenoside I and Their Distributions in Rats. Molecules. 2016 Jan 30;21(2):176.


[Related Small Molecules]

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Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
1179.3±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C54H92O24

[ Molecular Weight ]:
1125.294

[ Flash Point ]:
667.0±34.3 °C

[ Exact Mass ]:
1124.597900

[ PSA ]:
397.52000

[ LogP ]:
-0.77

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.632

[ Storage condition ]:
2-8℃

Related Compounds