B355252

Names

[ Name ]:
B355252

[Synonym ]:
2-Thiophenesulfonamide, 4-chloro-N-(1-naphthalenylmethyl)-5-[3-(1-piperazinyl)phenoxy]-
4-Chloro-N-(1-naphthylmethyl)-5-[3-(1-piperazinyl)phenoxy]-2-thiophenesulfonamide
MFCD28100813

Biological Activity

[Description]:

B355252, a phenoxy thiophene sulfonamide small molecule, is a potent NGF receptor agonist. B355252 potentiates NGF-induced neurite outgrowth. B355252 protects ischemic neurons from neuronal loss by attenuating DNA damage, reducing ROS production and the LDH level, and preventing neuronal apoptosis. B355252 has anti-apoptotic effects in glutamate-induced excitotoxicity, as well as in a murine hippocampal cell line (HT22) model of Parkinson disease (PD)[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Neurological Disease

[In Vivo]

B-355252 (0.125 mg/kg; ip; daily; 3 days) significantly attenuates the infarct volume and protects post-stroke neuronal loss in adult male Sprague–Dawley rats with cerebral ischemia[1].

[References]

[1]. Hao-Kuang Wang, et al. A Novel NGF Receptor Agonist B355252 Ameliorates Neuronal Loss and Inflammatory Responses in a Rat Model of Cerebral Ischemia. J Inflamm Res. 2021 Jun 1;14:2363-2376.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
718.4±70.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₅H₂₄ClN₃O₃S₂

[ Molecular Weight ]:
514.059

[ Flash Point ]:
388.3±35.7 °C

[ Exact Mass ]:
513.094788

[ LogP ]:
6.01

[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C

[ Index of Refraction ]:
1.666

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H315-H319-H335

[ Precautionary Statements ]:
P261-P301 + P310-P305 + P351 + P338

[ RIDADR ]:
UN 2811 6.1 / PGIII