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NH2-Ph-C4-acid-NH2-Me

Names

[ CAS No. ]:
1263819-48-2

[ Name ]:
NH2-Ph-C4-acid-NH2-Me

Biological Activity

[Description]:

PROTAC Linker 31 is a PROTAC linker, which refers to the Alkyl-Chain composition. PROTAC Linker 31 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl-Chain


[References]

[1]. Leverett CA, et al. Design, Synthesis, and Cytotoxic Evaluation of Novel Tubulysin Analogues as ADC Payloads. ACS Med Chem Lett. 2016 Aug 26;7(11):999-1004.

Chemical & Physical Properties

[ Molecular Formula ]:
C12H18N2O2

[ Molecular Weight ]:
222.28

[ Storage condition ]:
2-8°C

Related Compounds