Erythromycin Ethylsuccinate

Names

[ Name ]:
Erythromycin Ethylsuccinate

[Synonym ]:
ERYTHROMYCIN ETHYISUCCINATE
ERYTHROCINETHYLSUCCINATE
ErythromycinEthylsuccinate
Erythromycin ethylsuccinate
ERYTHROMYCIN ETHYL SUCCINATE
ERYTHROMYCIN ETHYLSUCCINATE API
(2S,3R,4S,6R)-4-(Dimethylamino)-2-{[(3S,4R,5R,6S,7S,9S,11S,12S,13R,14S)-14-ethyl-7,12,13-trihydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-3,5,7,9,11,13-hexamethyl-2,10-dioxooxacyclotetradecan-6-yl]oxy}-6-methyltetrahydro-2H-pyran-3-yl ethyl succinate
ERYTHROMYCIN ETHYLSUCCINATE, ANTIBIOTIC FOR CULTURE MEDIA USE ONLY

Biological Activity

[Description]:

Erythromycin Ethylsuccinate is an antibiotic useful for the treatment of a number of bacterial infections, has an antimicrobial spectrum similar to or slightly wider than that of penicillin.

[Related Catalog]:

Signaling Pathways >> Autophagy >> Autophagy

Signaling Pathways >> Anti-infection >> Bacterial

Research Areas >> Infection

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
874.1±65.0 °C at 760 mmHg

[ Melting Point ]:
219-224ºC

[ Molecular Formula ]:
C₄₃H₇₅NO₁₆

[ Molecular Weight ]:
862.053

[ Flash Point ]:
482.4±34.3 °C

[ Exact Mass ]:
861.508606

[ PSA ]:
226.28000

[ LogP ]:
4.10

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.529

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
ethanol: soluble50mg/mL | Freely soluble in organic solvents, practically insoluble in water

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WM9800000

CHEMICAL NAME :: Succinic acid, monoethyl ester, monoester with erythromycin

CAS REGISTRY NUMBER :: 1264-62-6

BEILSTEIN REFERENCE NO. :: 0077638

LAST UPDATED :: 199612

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C43-H75-N-O16

MOLECULAR WEIGHT :: 862.19

WISWESSER LINE NOTATION :: T-14-VO GVTJ C2 DQ D1 EQ F1 H1 JQ J1 L1 N1 KO- BT6OTJ CQ DN1&1 F1& MO- FT6OTJ B1 CQ DO1 D1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - child

DOSE/DURATION :: 420 mg/kg/7D-I

TOXIC EFFECTS :: Gastrointestinal - nausea or vomiting Liver - other changes

REFERENCE :: CMAJAX Canadian Medical Association Journal. (Canadian Medical Assoc., POB 8650, Ottawa, ON K1G 0G8, Canada) V.1- 1911- Volume(issue)/page/year: 129,411,1983

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 5714 ug/kg

TOXIC EFFECTS :: Behavioral - ataxia

REFERENCE :: AJEMEN American Journal of Emergency Medicine. (WB Saunders, Philadelphia, PA) V.1- 1983- Volume(issue)/page/year: 10,616,1992

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4167 mg/kg

TOXIC EFFECTS :: Gastrointestinal - hypermotility, diarrhea

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 9,445,1966

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,126,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M0949 No. of Facilities: 113 (estimated) No. of Industries: 2 No. of Occupations: 7 No. of Employees: 3065 (estimated) No. of Female Employees: 1433 (estimated)

Safety Information

[ Symbol ]:

GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H317-H334

[ Precautionary Statements ]:
P261-P280-P284-P304 + P340-P342 + P311

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R42/43

[ Safety Phrases ]:
S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ RTECS ]:
WM9800000

[ HS Code ]:
2941500000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2941500000

Articles

Hapten synthesis, monoclonal antibody production and development of a competitive indirect enzyme-linked immunosorbent assay for erythromycin in milk.

Food Chem. 171 , 98-107, (2014)

Erythromycin is an antibiotic used extensively in veterinary practice worldwide for treatment, prevention and growth promotion. In this work, monoclonal antibodies (Mabs) against erythromycin were pro...

Sensitive determination of tilmicosin, erythromycin ethylsuccinate and clindamycin by CE with electrochemiluminescence detection using azithromycin as internal standard and its applications.

J. Sep. Sci. 33(9) , 1305-11, (2010)

A sensitive approach for the simultaneous determination of tilmicosin, erythromycin ethylsuccinate and clindamycin was developed by CE coupled with electrochemiluminescence detection with ionic liquid...

Pharmacokinetics of erythromycin after the administration of intravenous and various oral dosage forms to dogs.

J. Vet. Pharmacol. Ther. 31(6) , 496-500, (2008)

The purpose of this study was to describe and compare the pharmacokinetic properties of different formulations of erythromycin in dogs. Erythromycin was administered as lactobionate (10 mg/kg, IV), es...