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E3 ligase Ligand 5

Names

[ CAS No. ]:
1264754-13-3

[ Name ]:
E3 ligase Ligand 5

[Synonym ]:
Benzonitrile, 4-[4-[(Z)-(2,4-dioxo-5-thiazolidinylidene)methyl]-2-methoxyphenoxy]-3-(trifluoromethyl)-
4-{4-[(Z)-(2,4-Dioxo-1,3-thiazolidin-5-ylidene)methyl]-2-methoxyphenoxy}-3-(trifluoromethyl)benzonitrile

Biological Activity

[Description]:

E3 ligase Ligand 5 is a ligand of E3 ligase, extracted from patent US 20160058872A1, Paragraph 0515. E3 ligase Ligand 5 can be used in PROTAC technology.

[Related Catalog]:

Signaling Pathways >> PROTAC >> Ligand for E3 Ligase
Research Areas >> Cancer

[Target]

Ligand for E3 Ligase[1]


[References]

[1]. Crew, Andrew P, et al. IMIDE-BASED MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE. US20160058872A1.


[Related Small Molecules]

E3 ligase Ligand 1 | TC E3 5031 | VH 298 | 2-(2,6-dioxopiperidin-3-yl)-4-hydroxyisoindoline-1,3-dione | Thalidomide fluoride | E3 ligase Ligand 6 | TNF-α-IN-1

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Molecular Formula ]:
C19H11F3N2O4S

[ Molecular Weight ]:
420.362

[ Exact Mass ]:
420.039154

[ LogP ]:
3.35

[ Index of Refraction ]:
1.628

[ Storage condition ]:
2-8℃

Related Compounds